Researchers in developing countries are more likely to publish in predatory journals (Xia et al., 2015). This study investigates the understanding that research scientists in Ghana, a developing country, have about predatory journals and their publishing practices. Using a mixed methods approach, research scientists within one cluster of research organizations in Ghana were asked about their awareness of the characteristics of predatory journals, based on their own experience as a researcher. Their publications were also examined. The results indicate that most of the research scientists in this study are aware of predatory journals and are often solicited by them, but are less aware of tools they can use to determine the quality of a particular publication. In addition, 12% of the articles published that make up 24% of the unique journals in which these researchers published could be considered “predatory”. The findings of this research are significant because they indicate that research scientists may have more awareness of predatory journals than is expected, but that they may lack the training or tools necessary for deciding whether or not a journal is legitimate.