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In this article, life skills training has been studied on reducing depression and increasing the self-esteem of mothers of mentally disabled children. One of the problems for parents of disabled children is their low level of self-esteem. Self-esteem can be the result of proper education in the environment, school, and society. Life skills training program leads to increasing individual self-esteem and empowers people with a variety of essential skills, realizing potential abilities and coping with different life situations. Research in the field of semi-experimental design and in the form of pretest-posttest with control group, A sample of 30 female volunteers were selected in the research program in an accessible manner and were randomly assigned to two groups of 15 individuals who were control and experimental. Life skills training also affects depression. Life skills that increase the power of adaptability and positive behavior. And the person accepts responsibility for his social role in the society without damaging himself or others. And face the challenges and problems of life effectively. The results show that there is a significant differences between the pre-test and post-test scores of the experimental group and the mean scores of self-esteem in the post-test are significantly higher than the mean scores of the pre-test; in the control group, there was no significant difference between the mean scores of pre-test and post-test.
