Culture exerts a fundamental effect on employees and their use of technologies. We examine the influence of culture (and other factors) on computer self-efficacy (CSE). CSE, or employees' judgments about their capabilities to use a specific software system, is important given its relationship with work performance. By drawing a sample from two different countries, we show that culture affects CSE indirectly through employees' preferences for individualism and task interdependence. Furthermore, individualism, task interdependence and software personal innovativeness relate positively, whereas task ambiguity and software complexity associate negatively with CSE. Finally, we discuss several implications for human resource management.