Learner-Centered, Information-Age schools have been proposed in Educational Technology and in other publications. This article reviews the experience of the New Technology Foundation, a school-development organization, working since 2001 to support 51 communities in 10 states to launch and implement 21 st Century High Schools, based on the model and practices of New Technology High School (NTHS) in Napa, California. This article explores the key issues and lessons in 21 st Century school development, encompassing a new learning culture.