This article aims to argue that evidence-based decision-making for a public health emergency is “easier said than done” reflected on COVID-19 response in China. For the local government, the behavioral pattern is prone to blame-avoiding instead of making decision following scientific evidence and experts’ advice. However, such behavior is not based on completely subjective judgment but a rational choice for the local government. Some consequences associated with China’s response to COVID-19 reveals an inflexible administrative system. Therefore, China’s governance reform should focus on empowering local governments with more flexibility and resilience, which enables local governments to make independent and scientific decisions in an emergency.