Professional associations serve as a backbone for their members in Africa and globally. They promote the welfare of their members and have standards and principles that guide their activities. This is a quantitative study of 10 national library associations in sub-Saharan Africa. The study looks at some of the activities of the national library associations and how they were impacted by the outbreak of COVID-19. The findings show that the majority of the associations had to postpone their annual conferences and continuous professional education programmes. The study recommends that national library associations from sub-Saharan Africa take advantage of technological platforms to reach out to their members in the organization of conferences and training programmes. Also, national library associations should have a policy that can drive their activities in the future in the event of the occurrence of another pandemic.