This paper analyses public support for government spending on science and technology (S&T) and its determinants. It constructs hypotheses based on previous findings from two streams of research: public preferences for government spending and public understanding of science. Using data from a large national survey in Spain, it develops multivariate models to test the relevance of various predictors of public support for government spending on S&T. Findings identify several variables that are clear and consistent predictors of public support for government spending on science and technology: the respondent’s educational level, interest and participation in science, knowledge of science, and positive values and views of science and technology. However, the effects of other variables also related with general attitudes toward science are less clearly associated with support for government spending on S&T.