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The state of San Luis Potosí (SLP) is divided into four regions: “Altiplano, Centro, Huasteca and Media”. A large socioeconomic inequality is perceived among the regions, this is especially observed when comparing Centro with the other regions, mainly because Centro region shows greater economic dynamism and has a great amount of companies, educational institutions and research centers, which contributes to lower its socioeconomic lag. In order to reduce the social inequality and the economic development gap of SLP, a project for the construction of innovation agendas with a regional focus was formulated applying RIS3 methodology. Therefore, this article has as its main objective, to present and analyze the results of this project, through the identification of regional economic potential and their areas of smart specialization, as well as international technological trends in those areas. As an important component, a governance mechanism was organized in the four regions used to build consensus and legitimate the RIS3 process. In the framework of triple- helix participatory workshops, a portfolio of priority innovation projects was defined. This article offers an analysis of favorable factors and obstacles faced during the process; a series of recommendations for the promotion of regional innovation agendas (RIA) plus brief conclusions
