The question of knowledge permeates our society since the days of the Greek Philosophers. According to some “knowledge” is what allows men to solve their everyday problems. This article goal is to conceptualize knowledge regarding the individual learning of the human being: in the eyes of the cognitivists; following the optics of connectionism; and in accordance with the autopoietic approach. By way of an epiphany we discuss the knowledge in an integrated vision that understands each of the three concepts as aspects of the same reality. Therefore, the methodology used was a descriptive exploratory research, a qualitative approach, which allowed, in the end, infers some considerations on the question of knowledge in a broader and more comprehensive approach.