Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity

• Cagri Camsari ^[2] ; Joseph K. Folger ^[2] ; Devin McGee ^[2] ; Steven J. Bursian ^[3] ; Hongbing Wang ^[4] ; Jason G. Knott ^[1] ; George W. Smith ^[2]
  1. [1] Michigan State University

     Michigan State University

     City of East Lansing, Estados Unidos

     
  2. [2] 1 Laboratory of Mammalian Reproductive Biology and Genomics,; 2 Department of Animal Science,
  3. [3] 2 Department of Animal Science,
  4. [4] 3 Department of Physiology,; 4 Neuroscience Program, and

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• Localización: Environmental health perspectives, ISSN 0091-6765, Vol. 125, Nº. 4, 2017, págs. 643-650
• Idioma: inglés
• DOI: 10.1289/EHP481
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• Resumen

  • Long-term exposure to the heavy metals cadmium (Cd) and mercury (Hg) is known to increase the risk of chronic diseases. However, to our knowledge, exposure to Cd and Hg beginning at the periconception period has not been studied to date.

    We examined the effect of Cd and Hg that were co-administered during early development on indices of chronic diseases in adult male mice.

    Adult female CD1 mice were subcutaneously administered a combination of cadmium chloride (CdCl2) and methylmercury (II) chloride (CH3HgCl) (0, 0.125, 0.5, or 2.0 mg/kg body weight each) 4 days before and 4 days after conception (8 days total). Indices of anxiety-like behavior, glucose homeostasis, endocrine and molecular markers of insulin resistance, and organ weights were examined in adult male offspring.

    Increased anxiety-like behavior, impaired glucose homeostasis, and higher body weight and abdominal adipose tissue weight were observed in male offspring of treated females compared with controls. Significantly increased serum leptin and insulin concentrations and impaired insulin tolerance in the male offspring of dams treated with 2.0 mg/kg body weight of Cd and Hg suggested insulin resistance. Altered mRNA abundance for genes associated with glucose and lipid homeostasis (GLUT4, IRS1, FASN, ACACA, FATP2, CD36, and G6PC) in liver and abdominal adipose tissues as well as increased IRS1 phosphorylation in liver (Ser 307) provided further evidence of insulin resistance.

    Results suggest that the co-administration of Cd and Hg to female mice during the early development of their offspring (the periconception period) was associated with anxiety-like behavior, altered glucose metabolism, and insulin resistance in male offspring at adulthood.

    Camsari C, Folger JK, McGee D, Bursian SJ, Wang H, Knott JG, Smith GW. 2017. Effects of periconception cadmium and mercury co-administration to mice on indices of chronic diseases in male offspring at maturity. Environ Health Perspect 125:643–650; http://dx.doi.org/10.1289/EHP481

• Referencias bibliográficas
  • (2012). Pathogenesis of type 2 diabetes. In:. Springer. New York.
  • Ayala, JE, Samuel, VT, Morton, GJ, Obici, S, Croniger, CM, Shulman, GI. (2010). Standard operating procedures for describing and performing...
  • Bailey, KR, Pavlova, MN, Rohde, AD, Hohmann, JG, Crawley, JN. (2007). Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like...
  • Barański, B, Stetkiewicz, I, Trzcinka-Ochocka, M, Sitarek, K, Szymczak, W. (1982). Teratogenicity, fetal toxicity and tissue concentration...
  • Barker, DJ. (1997). Maternal nutrition, fetal nutrition, and disease in later life.. Nutrition. 13. 807-813
  • Barker, DJ, Eriksson, JG, Forsén, T, Osmond, C. (2002). Fetal origins of adult disease: strength of effects and biological basis.. Int J Epidemiol....
  • Bekheet, SH. (2011). Comparative effects of repeated administration of cadmium chloride during pregnancy and lactation and selenium protection...
  • Beyrouty, P, Chan, HM. (2006). Co-consumption of selenium and vitamin E altered the reproductive and developmental toxicity of methylmercury...
  • Chen, CM, Chou, HC, Huang, LT. (2015). Maternal nicotine exposure during gestation and lactation induces kidney injury and fibrosis in rat...
  • Dési, I, Nagymajtényi, L, Schulz, H. (1998). Behavioural and neurotoxicological changes caused by cadmium treatment of rats during development.....
  • Dharuri, H, ’t Hoen, PA, van Klinken, JB, Henneman, P, Laros, JF, Lips, MA. (2014). Downregulation of the acetyl-CoA metabolic network in...
  • Fair, PH, Balthrop, JE, Braddon-Galloway, S. (1987). The toxicity, distribution and elimination of methylmercury in mice following intracerebral...
  • Feldman, SL, Squibb, KS, Cousins, RJ. (1978). Degradation of cadmium-thionein in rat liver and kidney.. J Toxicol Environ Health. 4. 805-813
  • Fredriksson, A, Gårdlund, AT, Bergman, K, Oskarsson, A, Ohlin, B, Danielsson, B. (1993). Effects of maternal dietary supplementation with...
  • Gandhi, DN, Panchal, GM, Dhull, DK. (2014). Neurobehavioral toxicity in progeny of rat mothers exposed to methylmercury during gestation.....
  • Gårdebjer, EM, Anderson, ST, Pantaleon, M, Wlodek, ME, Moritz, KM. (2015). Maternal alcohol intake around the time of conception causes glucose...
  • Ge, F, Zhou, S, Hu, C, Lobdell, HT, Berk, PD. (2010). Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis...
  • Hazelhoff Roelfzema, W, Roelofsen, AM, Herber, RF, Peereboom-Steg, JH. (1988). Cadmium and zinc concentrations in fetal and maternal rat tissue...
  • Head, WS, Orseth, ML, Nunemaker, CS, Satin, LS, Piston, DW, Benninger, RK. (2012). Connexin-36 gap junctions regulate in vivo first- and second-phase...
  • Hostetter, RC. (2013). Time of day effects on learning and open field activity.. Psychon Sci (1966). 5. 257-258
  • Huang, PL. (2009). A comprehensive definition for metabolic syndrome.. Dis Model Mech. 2. 231-237
  • Hughes, JA, Annau, Z. (1976). Postnatal behavioral effects in mice after prenatal exposure to methylmercury.. Pharmacol Biochem Behav. 4....
  • Jacquillet, G, Barbier, O, Rubera, I, Tauc, M, Borderie, A, Namorado, MC. (2007). Cadmium causes delayed effects on renal function in the...
  • Ji, YL, Wang, H, Liu, P, Zhao, XF, Zhang, Y, Wang, Q. (2011). Effects of maternal cadmium exposure during late pregnant period on testicular...
  • Koketsu, Y, Sakoda, H, Fujishiro, M, Kushiyama, A, Fukushima, Y, Ono, H. (2008). Hepatic overexpression of a dominant negative form of raptor...
  • Lau, JC, Joseph, MG, Cherian, MG. (1998). Role of placental metallothionein in maternal to fetal transfer of cadmium in genetically altered...
  • Magos, L, Butler, WH. (1976). The kinetics of methylmercury administered repeatedly to rats.. Arch Toxicol. 35. 25-39
  • Maia, CS, Lucena, GM, Corrêa, PB, Serra, RB, Matos, RW, Menezes, FC. (2009). Interference of ethanol and methylmercury in the developing central...
  • Marshall, OJ. (2004). PerlPrimer: cross-platform, graphical primer design for standard, bisulphite and real-time PCR.. Bioinformatics. 20....
  • McIlwrath, SL, Westlund, KN. (2015). Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.. World...
  • Minetti, A, Reale, CA. (2006). Sensorimotor developmental delays and lower anxiety in rats prenatally exposed to cadmium.. J Appl Toxicol....
  • Montgomery, KS, Mackey, J, Thuett, K, Ginestra, S, Bizon, JL, Abbott, LC. (2008). Chronic, low-dose prenatal exposure to methylmercury impairs...
  • Ngo, HT, Hetland, RB, Sabaredzovic, A, Haug, LS, Steffensen, IL. (2014). Environ Res. 132. 251-263
  • Onishchenko, N, Tamm, C, Vahter, M, Hökfelt, T, Johnson, JA, Johnson, DA. (2007). Developmental exposure to methylmercury alters learning...
  • Paniagua-Castro, N, Escalona-Cardoso, G, Chamorro-Cevallos, G. (2007). Glycine reduces cadmium-induced teratogenic damage in mice.. Reprod...
  • Petersson Grawé, K, Teiling-Gårdlund, A, Jalkesten, E, Oskarsson, A. (2004). Increased spontaneous motor activity in offspring after maternal...
  • Petrochelli Banzato, T, Godinho, AF, da Silva Zacarin, EC, Perobelli, JE, Dal Bianco Fernandez, C, Favareto, AP. (2012). Sperm quality in...
  • Pilones, K, Tatum, A, Gavalchin, J. (2009). Gestational exposure to mercury leads to persistent changes in T-cell phenotype and function in...
  • Rayburn, WF, Brennan, MC. (2011). Periconception warnings about prescribing opioids.. Am J Obstet Gynecol. 204. 281-282
  • Rex, A, Voigt, JP, Gustedt, C, Beckett, S, Fink, H. (2004). Anxiolytic-like profile in Wistar, but not Sprague–Dawley rats in the social interaction...
  • Ronco, AM, Montenegro, M, Castillo, P, Urrutia, M, Saez, D, Hirsch, S. (2011). Maternal exposure to cadmium during gestation perturbs the...
  • Rosenfeld, CS. (2012). Effects of maternal diet and exposure to bisphenol A on sexually dimorphic responses in conceptuses and offspring.....
  • Rull, A, Geeraert, B, Aragonès, G, Beltrán-Debón, R, Rodríguez-Gallego, E, García-Heredia, A. (2014). Rosiglitazone and fenofibrate exacerbate...
  • Sagiv, SK, Thurston, SW, Bellinger, DC, Amarasiriwardena, C, Korrick, SA. (2012). Prenatal exposure to mercury and fish consumption during...
  • Schneider, CA, Rasband, WS, Eliceiri, KW. (2012). NIH Image to ImageJ: 25 years of image analysis.. Nat Methods. 9. 671-675
  • Seet, EL, Yee, JK, Jellyman, JK, Han, G, Ross, MG, Desai, M. (2015). Maternal high-fat-diet programs rat offspring liver fatty acid metabolism.....
  • Shanik, MH, Xu, Y, Skrha, J, Dankner, R, Zick, Y, Roth, J. (2008). Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or...
  • Spulber, S, Rantamäki, T, Nikkilä, O, Castrén, E, Weihe, P, Grandjean, P. (2010). Effects of maternal smoking and exposure to methylmercury...
  • Thiering, E, Brüske, I, Kratzsch, J, Thiery, J, Sausenthaler, S, Meisinger, C. (2011). Prenatal and postnatal tobacco smoke exposure and development...
  • Thurston, SW, Bovet, P, Myers, GJ, Davidson, PW, Georger, LA, Shamlaye, C. (2007). Does prenatal methylmercury exposure from fish consumption...
  • Wang, ZQ, Zhang, XH, Yu, Y, Tipton, RC, Raskin, I, Ribnicky, D. (2013). Metabolism. 62. 1239-1249