Jakob Edler, Andrew D. James
We utilise conceptual frameworks from political science on agenda setting, policy entrepreneurship and the role of the European Commission to understand the emergence of a new research theme (security) under the Seventh Framework Programme. We open-up the “black box” of the European Commission and in so doing examine the controversies that emerged within the Commission as well as the critical role of mid-ranking officials in identifying and utilising a political window of opportunity provided by the 9/11 attacks on the United States. We emphasise ambiguity as a key feature in the complex process of framing and mobilisation and develop the idea of ambiguity as a multi-dimensional and dynamic phenomenon that changes its nature and function over the different stages of the agenda setting process. We argue that the understanding of science and technology policy making can benefit by applying this agenda setting approach and its emphasis on the origins of policy, the agenda setting process and the role of policy entrepreneurship.