The article sheds light on the history of a Jewish family of L’Aquila, the Buonomo, in the second half of the 15th century, within the broader framework of the Jewish presence in the Abruzzi and in Southern Italy. In the dynamic mercantile environment of L’Aquila, the Buonomo carried out several different economic activities from around the 1450s until the expulsion of the Jews from the Kingdom of Naples at the beginning of the 16th century.