Information security is one primary function of any information management system, ensuring protection of sensitive information like financial data, customers’ credentials and intellectual property from unauthorized and illegal access. The present study, while emphasizing on an effective implementation of information system, aimed to examine the impact of information security awareness (ISA) on self-efficacy to comply (SEC), attitude towards compliance (ATC) and intention to comply (IC) and the role of these constructs on information system implementation in the manufacturing industry in China. The study also examined the mediation role of SEC, ATC and IC among ISA and information system implementation. Data was gathered through surveys responded by a sample of 357 employees of the manufacturing industry in China. To check the data reliability and association among variables, smart-PLS was used, which indicated that ISA had a positive impact on SEC, ATC and IC and these constructs, in turn, positively impacted information system implementation. The results also exposed that SEC, ATC and IC significantly mediate among ISA and information system implementation in the manufacturing industry in China.