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Purpose: Children are regarded as the future architectures forevery society and their growth and health guarantee should be one of the major concerns for all societies. Since thalassemic children suffer from the most problems in their life quality dimensions, this present study has brought about making comparison between the impact of Family-based Empowerment Model and Collaborative Care Model on the Quality of life among Little Children Infected with Major Thalassemia. Materials and Methods: This present research has been implemented as clinical trial over 90 major thalassemic children who had the criterions to enter in our study. Samples were divided randomly and simply into family based tests group, collaborative care and control group (30 children for each group). Demographic questionnaires and life quality of children (peds Qol) have been completed before intervention and for the whole three groups and the family based empowerment model and collaborative care model have been implemented for test groups during 4 sessions each was 45 minutes. By the usage of statistic tests and SPSS software, the average scores for life quality has been compared in 1/5 month after intervention with information received before intervention. Findings: Based on the acquired results, there is a meaningful statistic difference for the all life quality dimensions (physical, emotional, social and educational) and the total score for the life quality after intervention for the family based test group and for the child and parents report (p<0/001). There was a meaningful statistical difference for the total life quality dimensions among collaborative care test group except the social dimension and we were also witness for the existence of a meaningful statistical difference for the physical and educational function in parents report. There was also a meaningful statistical difference for the emotional, social and educational dimensions in control group and child and parents report (p<0/001). Discussion and Conclusion: with regard to the improvement of the life quality for the major thalassemic children, it seems that the implementation of the family based empowerment model is more effective than collaborative care model, for that reason, it is suggested for the nurses working in this domain, to take advantage from this model.
