Avances en la terapia de la leucemia infantil

• Autores: Ricardo Masetti
• Localización: AmbioCiencias: revista de divulgación, ISSN 1988-3021, Nº. 15, 2017, págs. 5-20
• Idioma: español
• Enlaces
  • Texto completo
• Resumen

  • En esta revisión se describen las características generales de las formas más frecuentes de leucemia, especialmente de la leucemia infantil, que ha sido el modelo de estudio para la biología de la enfermedad. Además, se presentan nuevos abordajes terapeúticos para el tratamiento de este tipo de leucemia: inhibidores de las proteínas tirosina-quinasas, anticuerpos específicos frente a los antígenos expresados por el clon leucémico e inhibidores del proteosoma y de las enzimas ADN metiltransferasas. El artículo concluye con la revisión de la eficacia de las denominadas células CAR-T (células T con Receptores de Antígenos Quiméricos) frente a las células cancerígenas de leucemia.

• Referencias bibliográficas
  • Annesley, C.E. y Brown, P. (2015). Novel agents for the treatment of childhood acute leukemia.Therapeutic Advances in Hematology 6:61-79.
  • Brentjens, R.J., Rivière, I., Park, J.H., et al. (2011). Safety and persistence of adoptively transferred autologous CD19-targeted T cells...
  • Brown, P., Hunger, S.P., Smith, F.O., Carroll W.L. y Reaman G.H. (2009). Novel targeted drug therapies for the treatment of childhood acute...
  • Castaigne, S., Pautas, C., Terre, C., et al. (2012). Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid...
  • Chmielewski, M. y Abken, H. (2015). TRUCKs: the fourth generation of CARs. Expert Opinion on Biological Therapy 15:1145-1154.
  • Cortes, J., Thomas, D., Koller, C., et al. (2004). Phase I study of bortezomib in refractory or relapsed acute leukemias.ClinicalCancerResearch...
  • Crick, F. y Watson, J. (1953). Astructure for deoxyribosenucleic acid. Nature 171:3.
  • Cooper, B.W., Kindwall-Keller, T.L., Craig, M.D., et al. (2015). A phase I study of midostaurin and azacitidine in relapsed and elderly AML...
  • Cooper, T.M., Cassar, J., Eckroth, E., et al. (2016). Aphase I study of quizartinib combined with chemotherapy in relapsed childhood leukemia:...
  • Davila, M.L. y Brentjens, R.J. (2016). CD19-Targeted CAR T cells as novel cáncer immunotherapy for relapsed or refractory B-cell acute lymphoblastic...
  • Fan, M., Li, M., Gao, L., et al. (2017). Chimeric antigen receptors for adoptive T cell therapy inacutemyeloid leukemia. Journal ofHematology&Oncology...
  • Farber, S., Diamond, L.K., Mercer, R.D., Sylvester, R.F.J. y Wolff, J.A. (1948). Temporary remissions in acute leukemia in children produced...
  • Gamis, A.S., Alonzo, T.A., Meshinchi, S., et al. (2014). Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia...
  • Grupp, S.A., Kalos, M., Barrett, D., Aplenc, R., Porter, D.L. y Rheingold SR. (2013). Chimeric antigen receptor–modified T cells for acute...
  • Horton, T.M., Pati, D., Plon, S.E., et al. (2007). Aphase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory...
  • Hu, S., Niu, H., Inaba, H., et al. (2011). Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid...
  • Kell, W.J., Burnett, A.K., Chopra, R., et al. (2003). A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive...
  • Lee, S.J., Levitsky, K., Parlati, F., et al. (2016). Clinical activity of carfilzomib correlates with inhibition of multiple proteasome subunits:...
  • Masetti, R., Bertuccio, S.N., Astolfi, A., et al. (2017). Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene. Journal...
  • Meshinchi, S., Alonzo, T.A., Stirewalt, D.L., et al. (2006). Clinical implications of FLT3 mutations inpediatricAML.Blood 108:3654-3661.
  • Nguyen, B., Williams, A.B., Young, D.J., et al. (2017). FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase...
  • Patnaik MM. (2017). Midostaurin for the treatment of acute myeloid leukemia. Future Oncology 13:1853-1871.
  • Pession, A., Masetti, R., Rizzari, C., et al. (2013). Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of...
  • Pierro, J., Hogan, L.E., Bhatla, T. y Carroll W.L. (2017). New targeted therapies for relapsed pediatric acute lymphoblastic leukemia. Expert...
  • Pui, C.H. y Evans, W.E. (2006). Treatment of acute lymphoblastic leukemia. The New England Journal of Medicine 354:166-178.
  • Pui, C-H., Yang, J.J., Hunger, S.P., et al. (2015). Childhood acute lymphoblastic leukemia: progress throughcollaboration. Journal ofClinicalOncology...
  • Price, K.E., Saleem, N., Lee, G. y Steinberg, M. (2013). Potential of ponatinib to treat chronic myeloid leukemia and acute lymphoblastic...
  • Queudeville, M., Handgretinger, R. y Ebinger, M. (2017). Immunotargeting relapsed or refractory precursor B-cell acute lymphoblastic leukemia-role...
  • Raetz, E.A., Cairo, M. S. , Borowitz, M. J . , et a l . (2015). Re-induction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic...
  • Ribera, J-M., Ferrer, A., Ribera, J. y Genescà, E. (2015). Profile of blinatumomab and its potential in the treatment of relapsed/refractory...
  • Savoldo, B., Ramos, C.A., Liu, E. et al. (2011). CD28 costimulation improves expansión and persistence of chimeric antigen receptor–modified...
  • Shah, N.N., Stetler-Stevenson, M., Yuan, C.M., et al. (2015). Characterization of CD22 expression in acute lymphoblastic leukemia. Pediatric...
  • Sasaki, K., Jabbour, E.J., Ravandi, F., et al. (2016). Hyper-CVAD plus ponatinib versus hyper-CVAD plus dasatinib as frontline therapy for...
  • Strati, P., Kantarjian, H., Ravandi, F., et al. (2015). Phase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for...
  • Teachey, D.T., Grupp, S.A. y Brown, V.I. (2009). Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia...
  • Thiollier, C., Lopez, C.K., Gerby, B., et al. (2012). Characterization of novel genomic alterations and therapeutic approaches using acute...
  • Thomas, E.D., Lochte, H.L.Jr., Lu, W.C. y Ferrebee, J.W. (1957). Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy....
  • Walter, R.B., Appelbaum, F.R., Estey, E.H. y Bernstein, I.D. (2012). Acute myeloid leukemia stemcells andCD33-targeted immunotherapy. Blood...
  • Wei, G., Twomey, D., Lamb, J., et al. (2006). Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid...
  • Winters, A.C. y Bernt, K.M. (2017). MLL-rearranged leukemias—an update on science and clinical approaches .Frontiers in Pediatrics 5:4.