Associations between Unconventional Natural Gas Development and Nasal and Sinus, Migraine Headache, and Fatigue Symptoms in Pennsylvania

• Aaron W. Tustin ^[1] ; Annemarie G. Hirsch ^[2] ; Sara G. Rasmussen ^[1] ; Joan A. Casey ^[3] ; Karen Bandeen-Roche ^[4] ; Brian S. Schwartz ^[5]
  1. [1] 1 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
  2. [2] 2 Center for Health Research, Geisinger Health System, Danville, Pennsylvania, USA
  3. [3] 3 Robert Wood Johnson Health and Society Scholars Program, University of California, San Francisco, San Francisco and University of California, Berkeley, Berkeley, California, USA
  4. [4] 4 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
  5. [5] 1 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; 2 Center for Health Research, Geisinger Health System, Danville, Pennsylvania, USA; 5 Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

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• Localización: Environmental health perspectives, ISSN 0091-6765, Vol. 125, Nº. 2, 2017, págs. 189-197
• Idioma: inglés
• DOI: 10.1289/EHP281
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• Resumen

  • Unconventional natural gas development (UNGD) produces environmental contaminants and psychosocial stressors. Despite these concerns, few studies have evaluated the health effects of UNGD.

    We investigated associations between UNGD activity and symptoms in a cross-sectional study in Pennsylvania.

    We mailed a self-administered questionnaire to 23,700 adult patients of the Geisinger Clinic. Using standardized and validated questionnaire items, we identified respondents with chronic rhinosinusitis (CRS), migraine headache, and fatigue symptoms. We created a summary UNGD activity metric that incorporated well phase, location, total depth, daily gas production and inverse distance–squared to patient residences. We used logistic regression, weighted for sampling and response rates, to assess associations between quartiles of UNGD activity and outcomes, both alone and in combination.

    The response rate was 33%. Of 7,785 study participants, 1,850 (24%) had current CRS symptoms, 1,765 (23%) had migraine headache, and 1,930 (25%) had higher levels of fatigue. Among individuals who met criteria for two or more outcomes, adjusted odds ratios for the highest quartile of UNGD activity compared with the lowest were [OR (95% CI)] 1.49 (0.78, 2.85) for CRS plus migraine, 1.88 (1.08, 3.25) for CRS plus fatigue, 1.95 (1.18, 3.21) for migraine plus fatigue, and 1.84 (1.08, 3.14) for all three outcomes together. Significant associations were also present in some models of single outcomes.

    This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample.

    Tustin AW, Hirsch AG, Rasmussen SG, Casey JA, Bandeen-Roche K, Schwartz BS. 2017. Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania. Environ Health Perspect 125:189–197; http://dx.doi.org/10.1289/EHP281

• Referencias bibliográficas
  • Adgate, JL, Goldstein, BD, McKenzie, LM. (2014). Potential public health hazards, exposures and health effects from unconventional natural...
  • Bell, IR, Baldwin, CM, Schwartz, GE. (1998). Illness from low levels of environmental chemicals: relevance to chronic fatigue syndrome and...
  • Bhattacharyya, N. (2009). Contemporary assessment of the disease burden of sinusitis.. Am J Rhinol Allergy. 23. 392-395
  • Burch, RC, Loder, S, Loder, E, Smitherman, TA. (2015). The prevalence and burden of migraine and severe headache in the United States: updated...
  • Casey, JA, Curriero, FC, Cosgrove, SE, Nachman, KE, Schwartz, BS. (2013). High-density livestock operations, crop field application of manure,...
  • Casey, JA, Savitz, DA, Rasmussen, SG, Ogburn, EL, Pollak, J, Mercer, DG. (2016). Unconventional natural gas development and birth outcomes...
  • Charlson, ME, Pompei, P, Ales, KL, MacKenzie, CR. (1987). A new method of classifying prognostic comorbidity in longitudinal studies: development...
  • Drollette, BD, Hoelzer, K, Warner, NR, Darrah, TH, Karatum, O, O’Connor, MP. (2015). Elevated levels of diesel range organic compounds in...
  • (2015). Natural Gas Gross Withdrawals and Production..
  • Fokkens, WJ, Lund, VJ, Mullol, J, Bachert, C, Alobid, I, Baroody, F. (2012). EPOS 2012: European position paper on rhinosinusitis and nasal...
  • Friedman, DI, De ver Dye, T. (2009). Migraine and the environment.. Headache. 49. 941-952
  • (2013). Shale Energy Development’s Effect on the Posting, Bonding, and Maintenance of Roads in Rural PA..
  • Griffith, JP, Zarrouf, FA. (2008). A systematic review of chronic fatigue syndrome: don’t assume it’s depression.. Prim Care Companion J Clin...
  • Hastan, D, Fokkens, WJ, Bachert, C, Newson, RB, Bislimovska, J, Bockelbrink, A. (2011). Chronic rhinosinusitis in Europe—an underestimated...
  • Jackson, RB, Vengosh, A, Darrah, TH, Warner, NR, Down, A, Poreda, RJ. (2013). Increased stray gas abundance in a subset of drinking water...
  • Kassotis, CD, Tillitt, DE, Davis, JW, Hormann, AM, Nagel, SC. (2014). Estrogen and androgen receptor activities of hydraulic fracturing chemicals...
  • Kovats, S, Depledge, M, Haines, A, Fleming, LE, Wilkinson, P, Shonkoff, SB. (2014). The health implications of fracking.. Lancet. 383. 757-758
  • Lipsitch, M, Tchetgen Tchetgen, E, Cohen, T. (2010). Negative controls: a tool for detecting confounding and bias in observational studies.....
  • Lipton, RB, Bigal, ME, Diamond, M, Freitag, F, Reed, ML, Stewart, WF. (2007). Migraine prevalence, disease burden, and the need for preventive...
  • Lipton, RB, Dodick, D, Sadovsky, R, Kolodner, K, Endicott, J, Hettiarachchi, J. (2003). A self-administered screener for migraine in primary...
  • Maloney, KO, Yoxtheimer, DA. (2012). Production and disposal of waste materials from gas and oil extraction from the Marcellus Shale play...
  • Mitka, M. (2012). Rigorous evidence slim for determining health risks from natural gas fracking.. JAMA. 307. 2135-2136
  • (2015).
  • Paulik, LB, Donald, CE, Smith, BW, Tidwell, LG, Hobbie, KA, Kincl, L. (2015). Impact of natural gas extraction on PAH levels in ambient air.....
  • (2016). PA DEP Oil & Gas Reporting Website - Welcome..
  • (1988). Survey of procedures to control extreme sampling weights. Proceeding of the Survey Research Methods Section of the American Statistical...
  • Powers, M, Saberi, P, Pepino, R, Strupp, E, Bugos, E, Cannuscio, CC. (2015). Popular epidemiology and “fracking”: citizens’ concerns regarding...
  • Ranjith, G. (2005). Epidemiology of chronic fatigue syndrome.. Occup Med (Lond). 55. 13-19
  • Ricci, JA, Chee, E, Lorandeau, AL, Berger, J. (2007). Fatigue in the U.S. workforce prevalence and implications for lost productive work time....
  • Saberi, P, Propert, KJ, Powers, M, Emmett, E, Green-McKenzie, J. (2014). Field survey of health perception and complaints of Pennsylvania...
  • Sauro, KM, Becker, WJ. (2009). The stress and migraine interaction.. Headache. 49. 1378-1386
  • Shashy, RG, Moore, EJ, Weaver, A. (2004). Prevalence of the chronic sinusitis diagnosis in Olmsted County, Minnesota.. Arch Otolaryngol Head...
  • Sjöstrand, C, Savic, I, Laudon-Meyer, E, Hillert, L, Lodin, K, Waldenlind, E. (2010). Migraine and olfactory stimuli.. Curr Pain Headache...
  • Steinzor, N, Subra, W, Sumi, L. (2013). Investigating links between shale gas development and health impacts through a community survey project...
  • Tan, BK, Kern, RC, Schleimer, RP, Schwartz, BS. (2013). Chronic rhinosinusitis: the unrecognized epidemic.. Am J Respir Crit Care Med. 188....
  • Townsend, P. (1987). Deprivation.. J Soc Policy. 16. 125-146
  • (2010). TIGER/LineShapefiles (machine- readable datafiles)..
  • Werner, AK, Vink, S, Watt, K, Jagals, P. (2015). Environmental health impacts of unconventional natural gas development: a review of the current...