Male Breast Cancer Incidence and Mortality Risk in the Japanese Atomic Bomb Survivors – Differences in Excess Relative and Absolute Risk from Female Breast Cancer

• Mark P. Little ^[1] ; Damien M. McElvenny ^[2]
  1. [1] National Institutes of Health

     National Institutes of Health

     Estados Unidos

     
  2. [2] 2 Institute of Occupational Medicine, Edinburgh, United Kingdom
• Localización: Environmental health perspectives, ISSN 0091-6765, Vol. 125, Nº. 2, 2017, págs. 223-229
• Idioma: inglés
• DOI: 10.1289/EHP151
• Enlaces
  • Texto completo
• Resumen

  • There are well-known associations of ionizing radiation with female breast cancer, and emerging evidence also for male breast cancer. In the United Kingdom, female breast cancer following occupational radiation exposure is among that set of cancers eligible for state compensation and consideration is currently being given to an extension to include male breast cancer.

    We compare radiation-associated excess relative and absolute risks of male and female breast cancers.

    Breast cancer incidence and mortality data in the Japanese atomic-bomb survivors were analyzed using relative and absolute risk models via Poisson regression.

    We observed significant (p ≤ 0.01) dose-related excess risk for male breast cancer incidence and mortality. For incidence and mortality data, there are elevations by factors of approximately 15 and 5, respectively, of relative risk for male compared with female breast cancer incidence, the former borderline significant (p = 0.050). In contrast, for incidence and mortality data, there are elevations by factors of approximately 20 and 10, respectively, of female absolute risk compared with male, both statistically significant (p < 0.001). There are no indications of differences between the sexes in age/time-since-exposure/age-at-exposure modifications to the relative or absolute excess risk. The probability of causation of male breast cancer following radiation exposure exceeds by at least a factor of 5 that of many other malignancies.

    There is evidence of much higher radiation-associated relative risk for male than for female breast cancer, although absolute excess risks for males are much less than for females. However, the small number of male cases and deaths suggests a degree of caution in interpretation of this finding.

    Little MP, McElvenny DM. 2017. Male breast cancer incidence and mortality risk in the Japanese atomic bomb survivors – differences in excess relative and absolute risk from female breast cancer. Environ Health Perspect 125:223–229; http://dx.doi.org/10.1289/EHP151

• Referencias bibliográficas
  • (1973). Information theory and an extension of the maximum likelihood principle. In: 2nd International Symposium on Information Theory. Petrov...
  • Akaike, H. (1981). Likelihood of a model and information criteria.. J Econom. 16. 3-14
  • Baan, R, Straif, K, Grosse, Y, Secretan, B, El Ghissassi, F, Bouvard, V. (2007). Carcinogenicity of alcoholic beverages.. Lancet Oncol. 8....
  • Berrington de Gonzalez, A, Apostoaei, AI, Veiga, LHS, Rajaraman, P, Thomas, BA, Hoffman, FO. (2012). RadRAT: a radiation risk assessment tool...
  • Brinton, LA, Richesson, DA, Gierach, GL, Lacey, JV, Park, Y, Hollenbeck, AR. (2008). Prospective evaluation of risk factors for male breast...
  • (2012). Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from...
  • Fackenthal, JD, Marsh, DJ, Richardson, AL, Cummings, SA, Eng, C, Robinson, BG. (2001). Male breast cancer in Cowden syndrome patients with...
  • Ford, D, Easton, DF, Stratton, M, Narod, S, Goldgar, D, Devilee, P. (1998). Genetic heterogeneity and penetrance analysis of the BRCA1 and...
  • Greene, MH. (1997). Genetics of breast cancer.. Mayo Clin Proc. 72. 54-65
  • (1996). Methods for Estimating the Probability of Cancer from Occupational Radiation Exposure. IAEA-TECDOC-870..
  • (2015). IIAC Annual Report 2014/15..
  • (2007). The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103.. Ann ICRP. 37. 1-332
  • Land, CE, Hayakawa, N, Machado, SG, Yamada, Y, Pike, MC, Akiba, S. (1994). A case-control interview study of breast cancer among Japanese...
  • Landis, SH, Murray, T, Bolden, S, Wingo, PA. (1999). Cancer statistics, 1999.. CA Cancer J Clin. 49. 8-31
  • Little, MP, Boice, JD. (1999). Comparison of breast cancer incidence in the Massachusetts tuberculosis fluoroscopy cohort and in the Japanese...
  • Lobaccaro, JM, Lumbroso, S, Belon, C, Galtier-Dereure, F, Bringer, J, Lesimple, T. (1993). Male breast cancer and the androgen receptor gene.....
  • Marsh, DJ, Coulon, V, Lunetta, KL, Rocca-Serra, P, Dahia, PL, Zheng, Z. (1998). Mutation spectrum and genotype-phenotype analyses in Cowden...
  • (1989). Generalized Linear Models. 2nd ed. Monographs on Statistics and Applied Probability 37.. Chapman and Hall/CRC. Boca Raton, FL.
  • Muirhead, CR, O’Hagan, JA, Haylock, RGE, Phillipson, MA, Willcock, T, Berridge, GLC. (2009). Mortality and cancer incidence following occupational...
  • Nevanlinna, H, Bartek, J. (2006). The. Oncogene. 25. 5912-5919
  • (2006). Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2.. National Academies Press. Washington, DC.
  • (2004). Mortality Statistics: Cause. Series DH2 No. 30. Review of the Registrar General on Deaths by Cause, Sex and Age, in England and Wales,...
  • (2012). Cancer Statistics Registrations, England (Series MB1), No. 41, 2010.. Her Majesty’s Stationery Office. London, UK.
  • Ozasa, K, Shimizu, Y, Suyama, A, Kasagi, F, Soda, M, Grant, EJ. (2012). Studies of the mortality of atomic bomb survivors, Report 14, 1950–2003:...
  • Preston, DL, Mattsson, A, Holmberg, E, Shore, R, Hildreth, NG, Boice, JD. (2002). Radiation effects on breast cancer risk: a pooled analysis...
  • Preston, DL, Ron, E, Tokuoka, S, Funamoto, S, Nishi, N, Soda, M. (2007). Solid cancer incidence in atomic bomb survivors: 1958–1998.. Radiat...
  • Ron, E, Ikeda, T, Preston, DL, Tokuoka, S. (2005). Male breast cancer incidence among atomic bomb survivors.. J Natl Cancer Inst. 97. 603-605
  • Thomas, DB, Rosenblatt, K, Jimenez, LM, McTiernan, A, Stalsberg, H, Stemhagen, A. (1994). Ionizing radiation and breast cancer in men (United...
  • (2016). Division of Energy Employees Occupational Illness Compensation (DEEOIC)..
  • (2008). UNSCEAR 2006 Report. Annex A. Epidemiological Studies of Radiation and Cancer.. United Nations. New York.
  • Weiss, JR, Moysich, KB, Swede, H. (2005). Epidemiology of male breast cancer.. Cancer Epidemiol Biomarkers Prev. 14. 20-26
  • (2015). World Health Organization Statistical Information System (WHOSIS)..
  • Wooster, R, Mangion, J, Eeles, R, Smith, S, Dowsett, M, Averill, D. (1992). A germline mutation in the androgen receptor gene in two brothers...