A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children’s Study

• Lidia Mínguez-Alarcón ^[4] ; Oleg Sergeyev ^[1] ; Jane S. Burns ^[4] ; Paige L. Williams ^[5] ; Mary M. Lee ^[2] ; Susan A. Korrick ^[6] ; Luidmila Smigulina ^[7] ; Boris Revich ^[3] ; Russ Hauser ^[8]
  1. [1] Vavilov Institute of General Genetics

     Vavilov Institute of General Genetics

     Rusia

     
  2. [2] University of Massachusetts Medical School

     University of Massachusetts Medical School

     City of Worcester, Estados Unidos

     
  3. [3] Russian Academy of Sciences

     Russian Academy of Sciences

     Rusia

     
  4. [4] 1 Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
  5. [5] 4 Department of Biostatistics, and; 5 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
  6. [6] 1 Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; 7 Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
  7. [7] 3 Chapaevsk Medical Association, Chapaevsk, Samara Region, Russia
  8. [8] 1 Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; 5 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

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• Localización: Environmental health perspectives, ISSN 0091-6765, Vol. 125, Nº. 3, 2017, págs. 460-466
• Idioma: inglés
• DOI: 10.1289/EHP25
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• Resumen

  • Exposures to endocrine-disrupting chemicals during critical phases of testicular development may be related to poorer semen parameters. However, few studies have assessed the association between childhood organochlorine (OC) exposure and adult semen parameters.

    We examined whether peripubertal serum OC concentrations are associated with semen parameters among young Russian men.

    From 2003 through 2005, 516 boys were enrolled at age 8–9 years and followed for up to 10 years. Serum OCs were measured in the enrollment samples using high-resolution mass spectrometry. At 18–19 years, 133 young men provided 1 or 2 semen samples (256 samples) collected approximately 1 week apart, which were analyzed for volume, sperm concentration, and motility. Unadjusted and adjusted linear mixed models were used to examine the associations of quartiles of lipid-standardized concentrations of dioxins [2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated dibenzo-p-dioxins (PCDDs)], furans, polychlorinated biphenyls (PCBs), and corresponding toxic equivalents (TEQs) with semen parameters.

    The median (range) for TCDD was 2.9 (0.4–12.1) pg/g lipid and PCDD TEQ was 8.7 (1.0–36.0) pg TEQ/g lipid. Higher quartiles of TCDD and PCDD TEQs were associated with lower sperm concentration, total sperm count, and total motile sperm count (p-trends ≤ 0.05). The highest quartile of peripubertal serum TCDD concentrations was associated with a decrease (95% CI) of 40% (18, 66%), 29% (3, 64%), and 30% (2, 70%) in sperm concentration, total sperm count, and total motile sperm count, respectively, compared with the lowest quartile. Similar associations were observed for serum PCDD TEQs with semen parameters. Serum PCBs, furans, and total TEQs were not associated with semen parameters.

    Higher peripubertal serum TCDD concentrations and PCDD TEQs were associated with poorer semen parameters.

    Mínguez-Alarcón L, Sergeyev O, Burns JS, Williams PL, Lee MM, Korrick SA, Smigulina L, Revich B, Hauser R. 2017. A longitudinal study of peripubertal serum organochlorine concentrations and semen parameters in young men: the Russian Children’s Study. Environ Health Perspect 125:460–466; http://dx.doi.org/10.1289/EHP25

• Referencias bibliográficas
  • Arima, A, Kato, H, Ooshima, Y, Tateishi, T, Inoue, A, Muneoka, A. (2009). Reprod Toxicol. 28. 495-502
  • Baccarelli, A, Pfeiffer, R, Consonni, D, Pesatori, AC, Bonzini, M, Patterson, DG. (2005). Handling of dioxin measurement data in the presence...
  • Barr, JR, Maggio, VL, Barr, DB, Turner, WE, Sjödin, A, Sandau, CD. (2003). New high-resolution mass spectrometric approach for the measurement...
  • Bin-Abbas, B, Conte, FA, Grumbach, MM, Kaplan, SL. (1999). Congenital hypogonadotropic hypogonadism and micropenis: effect of testosterone...
  • (2010). Cambridge University Press. Cambridge, UK.
  • Burns, JS, Williams, PL, Sergeyev, O, Korrick, S, Lee, MM, Revich, B. (2011). Serum dioxins and polychlorinated biphenyls are associated with...
  • Carlsen, E, Giwercman, A, Keiding, N, Skakkebaek, NE. (1992). Evidence for decreasing quality of semen during past 50 years.. BMJ. 305. 609-613
  • el-Sabeawy, F, Wang, S, Overstreet, J, Miller, M, Lasley, B, Enan, E. (1998). Treatment of rats during pubertal development with 2,3,7,8-tetrachlorodibenzo-....
  • Faqi, AS, Dalsenter, PR, Merker, HJ, Chahoud, I. (1998). Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-....
  • Faure, AC, Viel, JF, Bailly, A, Blagosklonov, O, Amiot, C, Roux, C. (2014). Evolution of sperm quality in men living in the vicinity of a...
  • Grumbach, MM. (2002). The neuroendocrinology of human puberty revisited.. Horm Res. 572. 2-14
  • Jørgensen, N, Andersen, AG, Eustache, F, Irvine, DS, Suominen, J, Petersen, JH. (2001). Regional differences in semen quality in Europe.....
  • Jørgensen, N, Carlsen, E, Nermoen, I, Punab, M, Suominen, J, Andersen, AG. (2002). East-West gradient in semen quality in the Nordic-Baltic...
  • (2002).
  • Leijs, MM, Koppe, JG, Olie, K, van Aalderen, WM, Voogt, P, Vulsma, T. (2008). Delayed initiation of breast development in girls with higher...
  • Link, B, Gabrio, T, Zoellner, I, Piechotowski, I, Paepke, O, Herrmann, T. (2005). Biomonitoring of persistent organochlorine pesticides, PCDD/PCDFs...
  • Meeker, JD, Hauser, R. (2010). Exposure to polychlorinated biphenyls (PCBs) and male reproduction.. Syst Biol Reprod Med. 56. 122-131
  • Oguz, F, Ciftci, O, Aydin, M, Timurkaan, N, Beytur, A, Altintas, R. (2013). Aminoguanidine prevents testicular damage-induced-2,3,7,8-tetrachlorodibenzo-....
  • Paoli, D, Giannandrea, F, Gallo, M, Turci, R, Cattaruzza, MS, Lombardo, F. (2015). Exposure to polychlorinated biphenyls and hexachlorobenzene,...
  • Patterson, DG, Hampton, L, Lapeza, CR, Belser, WT, Green, V, Alexander, L. (1987). High-resolution gas chromatographic/high-resolution mass...
  • Patterson, DG, Turner, WE, Caudill, SP, Needham, LL. (2008). Total TEQ reference range (PCDDs, PCDFs, cPCBs, mono-PCBs) for the US population...
  • Phillips, DL, Pirkle, JL, Burse, VW, Bernert, JT, Henderson, LO, Needham, LL. (1989). Chlorinated hydrocarbon levels in human serum: effects...
  • Schecter, A, Cramer, P, Boggess, K, Stanley, J, Päpke, O, Olson, J. (2001). Intake of dioxins and related compounds from food in the U.S....
  • Schisterman, EF, Cole, SR, Platt, RW. (2009). Overadjustment bias and unnecessary adjustment in epidemiologic studies.. Epidemiology. 20....
  • Schultz, R, Suominen, J, Värre, T, Hakovirta, H, Parvinen, M, Toppari, J. (2003). Expression of aryl hydrocarbon receptor and aryl hydrocarbon...
  • Searle, SR, Speed, FM, Milliken, GA. (1980). Population marginal means in the linear model: an alternative to least square means.. Am Stat....
  • Sharpe, RM. (2006). Pathways of endocrine disruption during male sexual differentiation and masculinization.. Best Pract Res Clin Endocrinol...
  • Sharpe, RM, McKinnell, C, Kivlin, C, Fisher, JS. (2003). Proliferation and functional maturation of Sertoli cells, and their relevance to...
  • Sjödin, A, Jones, RS, Lapeza, CR, Focant, JF, McGahee, EE, Patterson, DG. (2004). Semiautomated high-throughput extraction and cleanup method...
  • Sönmez, M, Türk, G, Çeribaşı, AO, Sakin, F, Ateşşahin, A. (2011). Attenuating effect of lycopene and ellagic acid on 2,3,7,8-tetrachlorodibenzo-....
  • Swan, SH, Elkin, EP, Fenster, L. (2000). The question of declining sperm density revisited: an analysis of 101 studies published 1934–1996.....
  • Toft, G, Rignell-Hydbom, A, Tyrkiel, E, Shvets, M, Giwercman, A, Lindh, CH. (2006). Semen quality and exposure to persistent organochlorine...
  • Turner, W, DiPeitro, E, Lapeza, C, Green, V, Gill, J, Patterson, DG. (1997). A fast universal automated cleanup system for the isotope-dilution...
  • (2009). Summary of U.S. EPA Dioxin Workshop. February 18−20, 2009. Cincinnati, Ohio. EPA/600/R-09/027.. U.S. EPA, Office of Research and Development....
  • Van den Berg, M, Birnbaum, LS, Denison, M, De Vito, M, Farland, W, Feeley, M. (2006). The 2005 World Health Organization reevaluation of human...
  • (1999). Cambridge University Press. Cambridge, UK.
  • Williams, PL, Sergeyev, O, Lee, MM, Korrick, SA, Burns, JS, Humblet, O. (2010). Blood lead levels and delayed onset of puberty in a longitudinal...
  • (2010). Cambridge University Press. Cambridge, UK.