The Association between Ambient Fine Particulate Air Pollution and Lung Cancer Incidence: Results from the AHSMOG-2 Study

• Lida Gharibvand ^[2] ; David Shavlik ^[3] ; Mark Ghamsary ^[1] ; W. Lawrence Beeson ^[4] ; Samuel Soret ^[1] ; Raymond Knutsen ^[4] ; Synnove F. Knutsen ^[4]
  1. [1] Loma Linda University

     Loma Linda University

     Estados Unidos

     
  2. [2] 1 Adventist Health Study-2,
  3. [3] 2 Center for Nutrition, Healthy Lifestyle, and Disease Prevention, and
  4. [4] 1 Adventist Health Study-2,; 2 Center for Nutrition, Healthy Lifestyle, and Disease Prevention, and

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• Localización: Environmental health perspectives, ISSN 0091-6765, Vol. 125, Nº. 3, 2017, págs. 378-384
• Idioma: inglés
• DOI: 10.1289/EHP124
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• Resumen

  • There is a positive association between ambient fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) and incidence and mortality of lung cancer (LC), but few studies have assessed the relationship between ambient PM2.5 and LC among never smokers.

    We assessed the association between PM2.5 and risk of LC using the Adventist Health and Smog Study-2 (AHSMOG-2), a cohort of health conscious nonsmokers where 81% have never smoked.

    A total of 80,285 AHSMOG-2 participants were followed for an average of 7.5 years with respect to incident LC identified through linkage with U.S. state cancer registries. Estimates of ambient air pollution levels at participants’ residences were obtained for 2000 and 2001, the years immediately prior to the start of the study.

    A total of 250 incident LC cases occurred during 598,927 person-years of follow-up. For each 10-μg/m3 increment in PM2.5, adjusted hazard ratio (HR) with 95% confidence interval (CI) for LC incidence was 1.43 (95% CI: 1.11, 1.84) in the two-pollutant multivariable model with ozone. Among those who spent > 1 hr/day outdoors or who had lived 5 or more years at their enrollment address, the HR was 1.68 (95% CI: 1.28, 2.22) and 1.54 (95% CI: 1.17, 2.04), respectively.

    Increased risk estimates of LC were observed for each 10-μg/m3 increment in ambient PM2.5 concentration. The estimate was higher among those with longer residence at enrollment address and those who spent > 1 hr/day outdoors.

    Gharibvand L, Shavlik D, Ghamsary M, Beeson WL, Soret S, Knutsen R, Knutsen SF. 2017. The association between ambient fine particulate air pollution and lung cancer incidence: results from the AHSMOG-2 study. Environ Health Perspect 125:378–384; http://dx.doi.org/10.1289/EHP124Citation: Gharibvand L, Shavlik D, Ghamsary M, Beeson WL, Soret S, Knutsen R, Knutsen SF. 2017. The association between ambient fine particulate air pollution and lung cancer incidence: results from the AHSMOG-2 study. Environ Health Perspect 125:378–384; http://dx.doi.org/10.1289/EHP124

• Referencias bibliográficas
  • (2016). Cancer Facts & Figures 2016.. American Cancer Society. Atlanta, GA.
  • Attfield, MD, Schleiff, PL, Lubin, JH, Blair, A, Stewart, PA, Vermeulen, R. (2012). The Diesel Exhaust in Miners study: a cohort mortality...
  • Beelen, R, Hoek, G, van den Brandt, PA, Goldbohm, RA, Fischer, P, Schouten, LJ. (2008). Long-term exposure to traffic-related air pollution...
  • Beeson, WL, Abbey, DE, Knutsen, SF. (1998). Long-term concentrations of ambient air pollutants and incident lung cancer in California adults:...
  • Brown, KW, Sarnat, JA, Koutrakis, P. (2012). Concentrations of PM. J Expo Sci Environ Epidemiol. 22. 161-172
  • Butler, TL, Fraser, GE, Beeson, WL, Knutsen, SF, Herring, RP, Chan, J. (2008). Cohort profile: the Adventist Health Study-2 (AHS-2).. Int...
  • Chen, CL, Hsu, LI, Chiou, HY, Hsueh, YM, Chen, SY, Wu, MM. (2004). Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up...
  • Dockery, DW, Pope, CA, Xu, X, Spengler, JD, Ware, JH, Fay, ME. (1993). An association between air pollution and mortality in six US cities.....
  • Doll, R, Hill, AB. (1950). Smoking and carcinoma of the lung.. Br Med J. 2. 739-748
  • El-Zein, RA, Fenech, M, Lopez, MS, Spitz, MR, Etzel, CJ. (2008). Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer...
  • Hystad, P, Demers, PA, Johnson, KC, Carpiano, RM, Brauer, M. (2013). Long-term residential exposure to air pollution and lung cancer risk.....
  • (2013). IARC Scientific Publication No. 161. Air Pollution and Cancer..
  • Knibbs, LD, de Dear, RJ, Morawska, L. (2010). Effect of cabin ventilation rate on ultrafine particle exposure inside automobiles.. Environ...
  • Krewski, D, Lubin, JH, Zielinski, JM, Alavanja, M, Catalan, VS, Field, RW. (2005). Residential radon and risk of lung cancer: a combined analysis...
  • Lin, DY. (1994). Cox regression analysis of multivariate failure time data: the marginal approach.. Stat Med. 13. 2233-2247
  • Markowitz, SB, Levin, SM, Miller, A, Morabia, A. (2013). Asbestos, asbestosis, smoking, and lung cancer. New findings from the North American...
  • McHugh, MK, Lopez, MS, Ho, CH, Spitz, MR, Etzel, CJ, El-Zein, RA. (2013). Use of the cytokinesis-blocked micronucleus assay to detect gender...
  • Mirabelli, MC, Golan, R, Greenwald, R, Raysoni, AU, Holguin, F, Kewada, P. (2015). Modification of traffic-related respiratory response by...
  • Naess, Ø, Nafstad, P, Aamodt, G, Claussen, B, Rosland, P. (2007). Relation between concentration of air pollution and cause-specific mortality:...
  • Pope, CA, Burnett, RT, Thun, MJ, Calle, EE, Krewski, D, Ito, K. (2002). Lung cancer, cardiopulmonary mortality, and long-term exposure to...
  • Prizment, AE, Yatsuya, H, Lutsey, PL, Lubin, JH, Woodward, M, Folsom, AR. (2014). Smoking behavior and lung cancer in a biracial cohort: the...
  • Raaschou-Nielsen, O, Andersen, ZJ, Beelen, R, Samoli, E, Stafoggia, M, Weinmayr, G. (2013). Air pollution and lung cancer incidence in 17...
  • Raaschou-Nielsen, O, Beelen, R, Wang, M, Hoek, G, Andersen, Z, Hoffmann, B. (2016). Particulate matter air pollution components and risk for...
  • Siegel, RL, Miller, KD, Jemal, A. (2015). Cancer statistics, 2015.. CA Cancer J Clin. 65. 5-29
  • Sørensen, M, Schins, RP, Hertel, O, Loft, S. (2005). Transition metals in personal samples of PM. Cancer Epidemiol Biomarkers Prev. 14. 1340-1343
  • Vineis, P, Hoek, G, Krzyzanowski, M, Vigna-Taglianti, F, Veglia, F, Airoldi, L. (2006). Air pollution and risk of lung cancer in a prospective...
  • Weichenthal, S, Van Ryswyk, K, Kulka, R, Sun, L, Wallace, L, Joseph, L. (2015). In-vehicle exposures to particulate air pollution in Canadian...
  • Weiss, W. (1997). Cigarette smoking and lung cancer trends: a light at the end of the tunnel?. Chest. 111. 1414-1416
  • (2013). International Classification of Diseases for Oncology. Third Edition. First Revision..