We investigate the effect of economic globalization on domestic inflation in twenty-one new emerging economies over the period 1990–2009. The empirical analysis using dynamic panel data models shows that the effect of domestic and global economic slacks on domestic inflation in the new emerging economies has changed significantly since the end of the 1990s. Before the end of the 1990s, the domestic economic slack played a predominant role in driving domestic inflation. After the year 2000, however, the global economic slack played a significant and more important role in affecting domestic inflation. This finding implies that the prescription that central banks should specifically react to developments in global output is justified for the new emerging economies over the most recent decade