Efeito do tratamento por metotrexato, curcumina livre e nanoemulsificada sobre a artrite reumatoide induzida por adjuvante em ratos

• Autores: João Marcelo de Souza Baptista, Diogo Rodrigues Jimenes, Emanuel Gomes Ferreira, Karile Cristina da Costa Salomão, Melissa Cumani Aragão, Roberto Kenji Nakamura Cuman, Nilza Cristina Buttow, Carmem Patrícia Barbosa
• Localización: Cuadernos de Educación y Desarrollo, ISSN-e 1989-4155, Vol. 17, Nº. 3, 2025
• Idioma: portugués
• DOI: 10.55905/cuadv17n3-027
• Enlaces
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• Resumen

  • A Artrite Reumatoide (AR) é uma doença com grande prevalência em mulheres causando expressiva morbimortalidade. O metotrexato (MTX) e a curcumina são alternativas no tratamento da AR, e a nanoemulsificação da curcumina surge como uma estratégia para melhorar sua eficácia. Ratos albinos Holtzman foram subdivididos em controle (C), artrítico (AIA), artrítico tratado com curcumina livre (AIA-CL), artrítico tratado com nanoemulsões de curcumina (AIA-CN), artrítico tratado com metotrexato (AIA-MTX), artrítico tratado com curcumina livre e metotrexato (AIA-CL-MTX) e artrítico tratado com metotrexato e curcumina nanoemulsionada (AIA-CN-MTX). Cortes histológicos do joelho foram corados para avaliar área, densidade numérica dos condrócitos e espessura da cartilagem. Os grupos AIA-CN-MTX e AIA-CL-MTX mostraram redução significativa da área dos condrócitos no fêmur e maior densidade celular na tíbia em comparação a outros grupos. Para a espessura da cartilagem, houve diferença apenas entre AIA-MTX e AIA-CL-MTX no fêmur. Os resultados são relevantes para compreender os efeitos dos tratamentos na saúde da cartilagem articular.

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