Urolithiasis is a prevalent condition, especially in young adults, peaking in the third decade of life. In Brazil, it is one of the main causes of urological hospitalization, with notable growth in Sergipe. The clinical impact and costs to the public health system reinforce the need to understand the profile of patients in order to guide preventive actions. Descriptive ecological study with secondary data from Hospital Admission Authorizations (AIH) from SIH/SUS. There were 5,684 hospitalizations for urolithiasis (4.86/10.000 inhabitants), with significant variation between regions (p<0.001), notably Aracaju (10.70) and Propriá (2.00). From 2022 onwards, there was an increase in the number of hospitalizations. Elective admissions were more frequent than emergency admissions (2.81 vs. 2.04; p<0.001). The highest incidence occurred in the 50-59 age group (10.16), followed by the 40-49 age group. There was an association with race/color (p<0.001), with higher rates among Asians (9.09) and mixed-race individuals (5.11). Hospital mortality was 0.36%, with differences between regions (p<0.001), predominantly in Lagarto (1.27%) and Aracaju (0.55%). Urolithiasis has a high prevalence of hospitalizations, with significant variation between regions and age groups, being more frequent in adults between 40 and 59 years of age. The predominance of elective hospitalizations and stable average costs indicate control in hospital procedures. However, differences in mortality rates between regions point to possible inequalities in access and quality of care, which deserve attention for the improvement of health services.