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Nonsteroidal anti-inflammatory drugs are the most commonly used in inflammatory processes. However, their use is often accompanied by harmful and toxic side effects. Among the plants present in the diversity of Brazilian flora, there is Chenopodium ambrosioides, where there are several reports of its use in folk medicine, presenting immunostimulatory and antitumor action, among others. The WHO highlighted that C. ambrosioides is among the plants most used in traditional medicine worldwide. In view of this, the present study aims to evaluate the anti-inflammatory effect of Chenopodium ambrosioides. through a systematic review. The present work followed the PRISMA recommendations, the guiding question of the research was elaborated using the PICO acronym strategy. Three databases were used to search for articles: PubMed, Science Direct and Web of Science, using the descriptors in Health Sciences/Medical Subject Headings (DeCS/MeSH): Chenopodium ambrosioides, Dysphania ambrosoides, Mastruz, anti-inflammatory, Inflammation, which were combined during the search by the Boolean operators AND and OR. After the electronic search, we selected 12 studies out of 295. After the application of phase 1, 50 remained, which were directed to phase 2; of these, 12 were used for the present study. The studies included in this review reveal a promising potential of Chenopodium ambrosioides, both in animal models and in vitro systems, with the presence of bioactive compounds that play a significant role in the modulation of the inflammatory response. Thus, Chenopodium ambrosioides presents a promising profile as an anti-inflammatory agent, both in acute and chronic conditions.
