Short-Term Exposure to Urban Air Pollution and Influences on Placental Vascularization Indexes

• Karen Hettfleisch ^[1] ; Lisandra Stein Bernardes ^[1] ; Mariana Azevedo Carvalho ^[1] ; Luciana Duzolina Manfré Pastro ^[1] ; Sandra Elisabete Vieira ^[2] ; Silvia R. D. M. Saldiva ^[3] ; Paulo Saldiva ^[4] ; Rossana Pulcineli Vieira Francisco ^[1]
  1. [1] 1 Department of Obstetrics and Gynecology, and
  2. [2] 2 Department of Pediatrics, São Paulo University Medical School, São Paulo, Brazil
  3. [3] 3 Health Institute, State Health Secretariat, São Paulo, Brazil
  4. [4] 4 Institute of Advanced Studies of the University of São Paulo, São Paulo, Brazil

  Mostrar afiliaciones +
• Localización: Environmental health perspectives, ISSN 0091-6765, Vol. 125, Nº. 4, 2017, págs. 753-759
• Idioma: inglés
• DOI: 10.1289/EHP300
• Enlaces
  • Texto completo
• Resumen

  • It has been widely demonstrated that air pollution can affect human health and that certain pollutant gases lead to adverse obstetric outcomes, such as preeclampsia and fetal growth restriction.

    We evaluated the influence of individual maternal exposure to air pollution on placental volume and vascularization evaluated in the first trimester of pregnancy.

    This was a cross-sectional study on low-risk pregnant women living in São Paulo, Brazil. The women carried passive personal NO2 and O3 monitors in the week preceding evaluation. We employed the virtual organ computer-aided analysis (VOCAL) technique using three-dimensional power Doppler ultrasound to evaluate placental volume and placental vascular indexes [vascularization index (VI), flow index (FI), and vascularization flow index (VFI)]. We analyzed the influence of pollutant levels on log-transformed placental vascularization and volume using multiple regression models.

    We evaluated 229 patients. Increased NO2 levels had a significant negative association with log of VI (p = 0.020 and beta = –0.153) and VFI (p = 0.024 and beta = –0.151). NO2 and O3 had no influence on the log of placental volume or FI.

    NO2, an estimator of primary air pollutants, was significantly associated with diminished VI and VFI in the first trimester of pregnancy.

    Hettfleisch K, Bernardes LS, Carvalho MA, Pastro LD, Vieira SE, Saldiva SR, Saldiva P, Francisco RP. 2017. Short-term exposure to urban air pollution and influences on placental vascularization indexes. Environ Health Perspect 125:753–759; http://dx.doi.org/10.1289/EHP300

• Referencias bibliográficas
  • Araujo Júnior, E, Nardozza, LM, Nowak, PM, Rolo, LC, Guimarães Filho, HA, Moron, AF. (2011). Three-dimensional power Doppler placental vascularisation...
  • Bernardes, LS, Francisco, RP, Saada, J, Salomon, R, Ruano, R, Lortad-Jacob, S. (2011). Quantitative analysis of renal vascularization in fetuses...
  • Brook, RD, Rajagopalan, S, Pope, CA, Brook, JR, Bhatnagar, A, Diez-Roux, AV. (2010). Particulate matter air pollution and cardiovascular disease:...
  • Campbell, S. (2007). Placental vasculature as visualized by 3D power Doppler angiography and 3D color Doppler imaging.. Ultrasound Obstet...
  • Carneiro, MFH, Ribeiro, FQ, Fernandes-Filho, FN, Lobo, DJA, Barbosa, F, Rhoden, CR. (2011). Pollen abortion rates, nitrogen dioxide by passive...
  • Conceição, GM, Miraglia, SG, Kishi, HS, Saldiva, PH, Singer, JM. (2001). Air pollution and child mortality: a time-series study in São Paulo,...
  • Costa, S, Ferreira, J, Silveira, C, Costa, C, Lopes, D, Relvas, H. (2014). Integrating health on air quality assessment—review report on health...
  • de Almeida Pimenta, EJ, Silva de Paula, CF, Duarte Bonini Campos, JA, Fox, KA, Francisco, R, Ruano, R. (2014). Three-dimensional sonographic...
  • de André, CDS, de André, PA, Rocha, FM, Saldiva, PHN, de Oliveira, RC, Singer, JM. (2014). Reliability of reflectance measures in passive...
  • de Melo, JO, Soto, SF, Katayama, IA, Wenceslau, CF, Pires, AG, Veras, MM. (2015). Inhalation of fine particulate matter during pregnancy increased...
  • de Oliveira, BF, Chacra, AP, Frauches, TS, Vallochi, A, Hacon, S. (2014). A curated review of recent literature of biomarkers used for assessing...
  • de Paula, CF, Ruano, R, Campos, JA, Zugaib, M. (2008). Placental volumes measured by 3-dimensional ultrasonography in normal pregnancies from...
  • de Paula, CF, Ruano, R, Campos, JA, Zugaib, M. (2009). Quantitative analysis of placental vasculature by three-dimensional power Doppler ultrasonography...
  • Demir, R, Seval, Y, Huppertz, B. (2007). Vasculogenesis and angiogenesis in the early human placenta.. Acta Histochem. 109. 257-265
  • Guiot, C, Gaglioti, P, Oberto, M, Piccoli, E, Rosato, R, Todros, T. (2008). Is three-dimensional power Doppler ultrasound useful in the assessment...
  • Hadlock, FP. (1990). Sonographic estimation of fetal age and weight.. Radiol Clin North Am. 28. 39-50
  • Hafner, E, Metzenbauer, M, Stümpflen, I, Waldhör, T, Philipp, K. (2010). First trimester placental and myometrial blood perfusion measured...
  • Huster, KM, Haas, K, Schoenborn, J, McVean, D, Odibo, AO. (2010). Reproducibility of placental volume and vasculature indices obtained by...
  • Jauniaux, E, Burton, GJ. (2007). Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit.. Early...
  • Jones, NW, Hutchinson, ES, Brownbill, P, Crocker, IP, Eccles, D, Bugg, GJ. (2009). Placenta. 30. 130-135
  • Jones, NW, Raine-Fenning, NJ, Mousa, HA, Bradley, E, Bugg, GJ. (2011). Evaluating the intra- and interobserver reliability of three-dimensional...
  • Kaufmann, P, Black, S, Huppertz, B. (2003). Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation...
  • Khatib, N, Weiner, Z, Beloosesky, R, Vitner, D, Thaler, I. (2014). The effect of maternal supine position on umbilical and cerebral blood...
  • Martins, WP, Raine-Fenning, NJ, Ferriani, RA, Nastri, CO. (2010). Quantitative three-dimensional power Doppler angiography: a flow-free phantom...
  • Mayhew, TM. (2009). A stereological perspective on placental morphology in normal and complicated pregnancies.. J Anat. 215. 77-90
  • Mirowsky, J, Gordon, T. (2015). Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications.. J...
  • Morel, O, Pachy, F, Chavatte-Palmer, P, Bonneau, M, Gayat, E, Laigre, P. (2010). Correlation between uteroplacental three-dimensional power...
  • Odeh, M, Ophir, E, Maximovsky, O, Grinin, V, Bornstein, J. (2011). Placental volume and three-dimensional power Doppler analysis in prediction...
  • Odibo, AO, Goetzinger, KR, Huster, KM, Christiansen, JK, Odibo, L, Tuuli, MG. (2011). Placental volume and vascular flow assessed by 3D power...
  • Olmo, NR, Saldiva, PH, Braga, AL, Lin, CA, Santos Ude, P, Pereira, LA. (2011). A review of low-level air pollution and adverse effects on...
  • Pairleitner, H, Steiner, H, Hasenoehrl, G, Staudach, A. (1999). Three-dimensional power Doppler sonography: imaging and quantifying blood...
  • Pedersen, M, Giorgis-Allemand, L, Bernard, C, Aguilera, I, Andersen, AM, Ballester, F. (2013). Ambient air pollution and low birthweight:...
  • Pedersen, M, Stayner, L, Slama, R, Sørensen, M, Figueras, F, Nieuwenhuijsen, MJ. (2014). Ambient air pollution and pregnancy-induced hypertensive...
  • Pomorski, M, Zimmer, M, Fuchs, T, Florjanski, J, Pomorska, M, Tomialowicz, M. (2014). Quantitative assessment of placental vasculature and...
  • Raine-Fenning, NJ, Clewes, JS, Kendall, NR, Bunkheila, AK, Campbell, BK, Johnson, IR. (2003). The interobserver reliability and validity of...
  • Raine-Fenning, NJ, Nordin, NM, Ramnarine, KV, Campbell, BK, Clewes, JS, Perkins, A. (2008). Determining the relationship between three-dimensional...
  • Raine-Fenning, NJ, Nordin, NM, Ramnarine, KV, Campbell, BK, Clewes, JS, Perkins, A. (2008). Evaluation of the effect of machine settings on...
  • Rizzo, G, Capponi, A, Pietrolucci, ME, Arduini, D. (2009). Effects of maternal cigarette smoking on placental volume and vascularization measured...
  • Romão, R, Pereira, LA, Saldiva, PH, Pinheiro, PM, Braga, AL, Martins, LC. (2013). The relationship between low birth weight and exposure to...
  • Sapkota, A, Chelikowsky, AP, Nachman, KE, Cohen, AJ, Ritz, B. (2012). Exposure to particulate matter and adverse birth outcomes: a comprehensive...
  • Schlembach, D, Wallner, W, Sengenberger, R, Stiegler, E, Mörtl, M, Beckmann, MW. (2007). Angiogenic growth factor levels in maternal and fetal...
  • (2003). Wiley-Interscience. Hoboken, NJ.
  • Shah, PS, Balkhair, T. (2011). Air pollution and birth outcomes: a systematic review.. Environ Int. 37. 498-516
  • Steinle, S, Reis, S, Sabel, CE. (2013). Quantifying human exposure to air pollution—moving from static monitoring to spatio-temporally resolved...
  • van den Hooven, EH, de Kluizenaar, Y, Pierik, FH, Hofman, A, van Ratingen, SW, Zandveld, PY. (2011). Air pollution, blood pressure, and the...
  • Veras, MM, Damaceno-Rodrigues, NR, Caldini, EG, Maciel Ribeiro, AA, Mayhew, TM, Saldiva, PH. (2008). Particulate urban air pollution affects...
  • (2010). Morgan & Claypool Life Sciences. San Rafael, CA.
  • Yorifuji, T, Naruse, H, Kashima, S, Murakoshi, T, Doi, H. (2015). Residential proximity to major roads and obstetrical complications.. Sci...
  • Zalud, I, Shaha, S. (2008). Three-dimensional sonography of the placental and uterine spiral vasculature: influence of maternal age and parity.....